DISEASE SUMMARY PAGE

Borrelia burgdorferi Infection in Lagomorphs and Bears

Summary Information
Diseases / List of Bacterial Diseases / Disease summary
Alternative Names
  • Lyme disease
  • Borreliosis
  • Lyme borreliosis
Disease Agents Borrelia burgdorferi
Infectious Agent(s)

Vectors:

Non-infectious Agent(s) --
Physical Agent(s) --
General Description
Clinical signs
  • Clinical signs of infection with Borrelia burgdorferi have not been reported in naturally infected wild lagomorphs but lagomorphs may act as reservoirs of Borrelia burgendorferi, since they harbour the organism and competent enzootic and bridge vectors feed on them. (B209.26.w26, J203.21.w1)
Further Information
Occurrence
In Lagomorphs

Wild lagomorphs that have been reported to be naturally infected with Borrelia burgdorferi:

  • Lepus californicus - Black-tailed Jackrabbit in North America. (B209.26.w26)
    • In regions where Lyme disease is endemic, the jackrabbit is especially likely to be infected. Thus, serological monitoring of jackrabbits is a useful means of surveying various geographical areas for the presence of borreliosis. (B614.8.w8)
    • In a study in California, 58/73 (79%) Lepus californicus - Black-tailed jackrabbit were seropositive for Borrelia burgendorferi by indirect IFA, and 1/26 (4%) was positive for spirochetemia with a direct IFA. (J1.24.w17)
    • In a study in southern Texas, 8/26 Lepus californicus - Black-tailed jackrabbit sampled in 1986 were seropositive for Borrelia burgendorferi (IFA at least 1:128) and Borrelia burgendorferi was isolated from 2/10 kidneys. (J1.25.w14)
  • Lepus europaeus - Brown hare in Europe. (B209.26.w26)
    • Sampling of ticks (nymphal Ixodes ricinus derived from blood-engorged larvae) collected from) Lepus europaeus - Brown hare near Stockholm, Sweden, detected Borrelia burgendorferi. (J110.30.w2)
  • Lepus timidus - Mountain hare 
    • This species of lagomorph has been reported to be a reservoir of disease in Europe. (B209.26.w26)
      • Sampling of ticks (nymphal Ixodes ricinus derived from blood-engorged larvae) collected from) Lepus timidus - Mountain hare near Stockholm, Sweden, detected Borrelia burgendorferi. (J110.30.w2)
    • In the Baltic Sea Islands, this species of lagomorph and Ixodes ricinus (Ixodidae (Family)) are reported to maintain an endemic cycle of Borrelia burgdorferi. (B209.26.w26)
      • A study on two isolated islands in the Baltic Sea, where Lepus timidus - Mountain hare is the only terrestrial vertebrate species able to act as a host for all stages of Ixodes ricinus, the organism was found in 11-24% of nymphal Ixodes ricinus fed as larvae on the hares as well as in 8-19% of host-seeking nymphal Ixodes ricinus collected from vegetation. The study concluded that the hare served as a maintenance host for Borrelia burgendorferi on these islands. (J110.33.w1)
  • Sylvilagus bachmani - Brush rabbit in North America. (B209.26.w26)
  • Sylvilagus floridanus - Eastern Cottontail rabbit (B614.8.w8)
    • In a study in the northeastern United States, more than 90% of rabbits sampled in the area over a period of two years were seropositive for Borrelia burgendorferi (ELISA and immunoblotting). (J91.41.w1)This species of lagomorph has been reported to be a reservoir of disease in North America. (B209.26.w26)
      • In the northeastern United States, this species of lagomorph and Ixodes dentatus (Ixodidae (Family)) are reported to maintain an endemic cycle of Borrelia burgdorferi. (B209.26.w26)
      • In a study in the northeastern United States, Borrelia burgendorferi was present in Ixodes dentatus ticks from all of 11 Sylvilagus floridanus - Eastern Cottontail rabbit sampled. (J91.41.w1)
      • In a study in New York State, USA, sprirochetes identified as Borrelia burgendorferi. were isolated from Sylvilagus floridanus - Eastern Cottontail rabbit in both rural and urban areas. It was noted that there was antigenic variability in the organism. (J93.27.w1)
  • Sylvilagus audubonii - Desert cottontail

There have been no reports of spontaneous infection in laboratory rabbits (Oryctolagus cuniculus domesticus - Domestic European rabbit). (B614.8.w8)

In Bears
  • A Borrelia sp. morphologically and antigenically similar to Borrelia burgdorferi, was isolated from the blood of two bears and the kidney of a third bear, out of 18 free-ranging Ursus americanus - American black bears from northern Wisconsin, 1983. (J1.24.w9) 
  • In a survey, a high rate of seropositivity to Borrelia burgendorferi (sensu lato) was detected in Ursus americanus - American black bears from inland forest habitats of northern California. (P9.2004.w7) 
Transmission
In Lagomorphs
  • In Europe, sampling of ticks (nymphal Ixodes ricinus derived from blood-engorged larvae) collected from) Lepus europaeus - Brown hare and Lepus timidus - Mountain hare near Stockholm, Sweden, detected Borrelia burgendorferi. The study showed that these hares are competent reservoirs. It also noted that since these species are capable of supporting all life stages of Ixodes ricinus, they could maintain the spirochete in the absence of other reservoir hosts such as rodents. (J110.30.w2)
  • In a study in California, Lepus californicus - Black-tailed jackrabbit of the five species of ticks (Dermocentor occidentalis, Dermacentor parumapertus, Ixodes neotomae, Ixodes perfidus, and Haemaphysalis leporispalustris) caried by the jackrabbits, Borrelia burgendorferi was detected in 20% of Ixodes neotomae and in 1% of Haemaphysalis leporispalustris; an infected Haemaphysalis leporispalustris female passed spirochetes to about 67% of her progeny (transovarial transmission). (J1.24.w17)
  • In a study in New York state, the organism was isolated from Ixodes dentatus but not from Haemaphysalis leporispalustris. (J93.27.w1)
  • Sylvilagus floridanus - Eastern Cottontail rabbit has been reported to be a reservoir of Borrelia burgendorferi in North America; in the northeastern United States, this species and Ixodes dentatus (Ixodidae (Family)) are reported to maintain an endemic cycle. (B209.26.w26)
    • In a study in the northeastern United States, Borrelia burgendorferi was present in Ixodes dentatus ticks from all of 11 Sylvilagus floridanus - Eastern Cottontail rabbit sampled, and was found in 32% of 72 unfed Ixodes dentatus nymphs collected by a sweep of the vegetation. More than 90% of rabbits sampled in the area over a period of two years were seropositive for Borrelia burgendorferi (ELISA and immunoblotting). (J91.41.w1)
Associated Techniques
Host taxa groups /species
Disease Author Nikki Fox BVSc MRCVS (V.w103); Gracia Vila-Garcia DVM, MSc, MRCVS (V.w67); Dr Debra Bourne MA VetMB PhD MRCVS (V.w5)
Referees Frances Harcourt-Brown BVSc FRCVS (V.w140)

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