| Chemicals / Complex Chemical Agents/ Chemical: |
| Prednisolone (with special reference to Ruminants, Hedgehogs, Elephants and Bears) |
| GENERAL CHEMICAL INFORMATION | THERAPEUTIC INFORMATION [DOSE, FREQUENCY & ROUTE] | NUTRITIONAL INFORMATION |
| TOXICITY INFORMATION | ENVIRONMENTAL INFORMATION |
|
General Chemical Information
| Summary |
|---|
| Synthetic glucocorticoid (steroid) anti-inflammatory drug. (B263) |
| Names and Formulae | |
|---|---|
| Type | Synthetic glucocorticoid. (B263) |
| Alternative Names | "Metacortandralone; delta1-dehydrocortisol; delta1-hydrocortisone; 1,4-pregnadiene-3,20-dione-11b,17a,21-triol; 11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione; (11b)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione; 1,4-Pregnadiene-11b,17a,21-triol-3,20-dione; 3,20-Dioxo-11b,17a,21-trihydroxy-1,4-pregnadiene; D1-Dehydrohydrocortisone; Hydroretrocortine; Decaprednil; Meticortelone; Ultracortene-H; Precortilon; PreCortisyl; Precortancyl; Cortalone; Predniretard; Predniliderm; Solone; Prednicen; Dicortol; Hefasolon; Hydeltra; Klismacort; Delta-Cortef; Deltastab; Paracortol; Deltisolone; Codelcortone; Hydrodeltisone; Prenolone; Hydrodeltalone; Sterolone; Sterane; Prednelan; Decortin H; Deltacortril; Scherisolon; Di-Adreson-F; Hostacortin H; Nisolone; Ropredlone; Flamasone; Predonin; 11beta,17alpha,21-Trihydroxypregna-1,4-diene-3,20-dione." (W324) |
| Chemical Formula | C21H28O5 (W324) |
| Chemical Structure | |
| Molecular Weight | 360.4492. (W324) |
| Related Chemicals | Prednisone (in vivo is converted in the liver to prednisolone). (B263) |
| Physical Properties / Chemistry | |
|---|---|
| Appearance |
|
| Melting point | 240°C (dec) (W324) |
| Boiling point | -- |
| Density | -- |
| Water solubility |
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| Other solubility |
|
| Acid/Base | -- |
| Pharmacology & General Information | |
|---|---|
| Pharmacology | -- |
| Storage / Stability | |
| Legal Category (In UK) | POM (B266) |
| References | |
|---|---|
Associated Techniques |
-- |
ORGANISATIONS |
-- |
| -- | |
| Authors | Debra Bourne (V.w5); Gracia Vila-Garcia (V.w67) |
| Referees | Suzanne I. Boardman (V.w6); Becki Lawson (V.w26); Susan Mikota (V.w72) |
Therapeutic Information
| Uses/Indications | |
|---|---|
| Activity | -- |
| Appropriate Use | |
| Limitations | -- |
| Notes | -- |
| Pharmacokinetics and Drug Interactions | |
|---|---|
| Absorption /Bioavailability | -- |
| Distribution | -- |
| Plasma Protein binding / Storage | -- |
| Elimination Route | -- |
| Elimination half-life / Clearance Rate | -- |
| Drug Interactions | Prednisolone
sodium phosphate:
|
| Administration | ||
|---|---|---|
| Formulations available |
|
|
| Doses / Administration Routes / Frequencies |
Use of Drugs (Medication):
Erinaceus europaeus - West European Hedgehog:
Elephants:
The following information is taken with permission directly from the Elephant Care International website (W580.Aug2005.w29):
Bears:
|
|
| Monitoring parameters | -- | |
| Withdrawal period / Withholding time | |
|---|---|
| Notes | Before the use of any pharmaceutical product in food-producing animals the label instructions for the product should be consulted regarding withdrawal requirements. |
Toxic Information
| Toxic effects of Pharmaceutical Products | |
|---|---|
| Contraindications / Precautions |
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| Adverse Effects / Side Effects / Warnings |
Reported side effects from glucocorticoid treatment include effects on blood cells and blood chemistry, central nervous system, endocrine system, gastro-intestinal system, renal system, musculoskeletal system and skin, as well as reduction in growth, redistribution of body fat, increased risk of infection, enhanced spread of infection and poor wound healing. (B270.33.w33) |
| Operator Warnings | Before the use of any pharmaceutical product the label instructions for the product should be consulted regarding operator safety/warnings. |
| Overdose / Acute Toxicity | -- |
| Detailed Toxicological Information | |
|---|---|
| Classification | -- |
| Acute Toxicity | -- |
| Chronic Toxicity | -- |
| Reproductive effects | -- |
| Teratogenic effects | -- |
| Mutagenic effects | -- |
| Carcinogenic effects |
-- |
| Organ toxicity | -- |
| Bird Toxicity | -- |
| Aquatic organism activity | -- |
| Other organism toxicity | -- |
Nutrient Information
| Nutritional Data | |
|---|---|
| Sources | -- |
| Biological Use | -- |
| Recommended Daily Allowance / Recommended level in food | -- |
| Stability in food (Storage time) | -- |
| Interactions | -- |
External / Environmental Information
| External / Environmental Uses | |
|---|---|
| Use | -- |
| Formulation | -- |
| Application method | -- |
| Application Concentration | -- |
| Persistence of Effect / Frequency of Application | -- |
| Sources in the Environment | |
|---|---|
| Natural sources | -- |
| Human-associated sources | -- |
| Effects on the Environment | |
|---|---|
| Effects in the aquatic environment |
-- |
| Effects on land | -- |
| Persistence in the Environment | |
|---|---|
| Breakdown in soil and groundwater |
-- |
| Breakdown in water | -- |
| Breakdown in vegetation | -- |